疾病预防与控制杂志

膝骨关节炎（KOA）是一种高发于中老年人的慢性退行性骨关节病，主要表现为关节痛、运动功能不全，是一种常见的致残性疾病，如不及时的给予针对性的治疗，可能严重影响患者的生活质量。针刀是我国传统医学的一种特色疗法，在缓解膝骨关节炎疼痛的同时，能有效地延缓疾病的发展。独活寄生汤是中医临床治疗膝骨性关节炎的经典方，多组分、多靶点、多成分联合治疗的作用机制是治疗膝骨性关节炎的关键问题。研究发现独活寄生汤具有显著的生物活性，但其药效作用机制尚未阐明，制约了临床上的应用与推广。研究显示，独活寄生汤可通过调节炎性因子、细胞凋亡、软骨细胞代谢及软骨基质降解等多种途径发挥抗炎、抗氧化作用，改善骨代谢，减轻软骨损伤。基于此，本研究对针刀联合独活寄生汤治疗膝骨关节炎的作用机制与研究进展进行综述，探讨膝骨关节炎从经筋失衡到软骨修复的新路径，为临床治疗工作的开展提供思路。

Knee osteoarthritis(KOA) is a chronic degenerative joint disease that predominantly affects middleaged and elderly individuals. Its primary manifestations include joint pain and impaired motor function. As a common disabling condition, KOA can significantly impact patients' quality of life if not promptly treated with targeted therapies. Acupotomy, a distinctive therapy in traditional Chinese medicine, not only alleviates the pain associated with KOA but also effectively delays the progression of the disease. Duhuo Jisheng Decoction, a classic prescription in clinical Chinese medicine for treating KOA, represents a key scientific issue in the treatment of this condition, given its multi-component, multi-target, and multi-ingredient combined therapy approach. Studies have found that Duhuo Jisheng Decoction exhibits significant biological activity, yet its pharmacodynamic mechanism remains unclear, limiting its clinical application and promotion. Research indicates that Duhuo Jisheng Decoction exerts anti-inflammatory and antioxidant effects through various pathways, including modulation of inflammatory factors, cell apoptosis, chondrocyte metabolism, and cartilage matrix degradation, thereby improving bone metabolism and reducing cartilage damage. Based on this, this study reviews the mechanism and research progress of acupotomy combined with Duhuo Jisheng Decoction in the treatment of KOA, explores a new pathway from meridian imbalance to cartilage repair in KOA, and provides insights for clinical treatment practices.